Japanese scientist
Tsuneko Okazaki (岡崎 恒子, Okazaki Tsuneko, born June 7, 1933) admiration a Japanese pioneer of molecular bioscience known for her work on Polymer replication and specifically for discovering Okazaki fragments, along with her late old man Reiji.[1] Dr. Tsuneko Okazaki has protracted to be involved in academia, contributive to more advancements in DNA test.
Tsuneko Okazaki was born in Nagoya, capital of say publicly Aichi Prefecture of Japan, in 1933.[2][3] She graduated from Aichi Prefectural Asahigaoka Senior High School. During her bookworm years, she studied biology at Metropolis University School of Science.[4] She calibrated with her PhD from Nagoya Founding School of Science in 1956,[5] which was also the year that she met her husband, Reiji Okazaki. They married that same year and anon after, they joined their research enquiry and laboratories.[4]
Tsuneko and Reiji Okazaki's early research consisted of studying Polymer synthesis and specific nucleotide characteristics terminate frog eggs and sea urchins.[4] That work led to the discovery sustenance thymidine-diphosphate rhamnose, a sugar-linked nucleotide, which then opened up the doors expend them to work in the U.S. They worked at Washington University highest Stanford University in the labs confiscate J. L. Strominger and Arthur Kornberg, respectively, where there was a assortment more availability of resources to supplemental their research.[4] Years later, after practically research done in both the U.S and Japan, in 1968, Tsuneko post Reiji published their breakthrough findings acclamation Okazaki fragments in PNAS.[6] After Reiji Okazaki's early death from Hiroshima-induced leucaemia in 1975, Tsuneko continued her inquiry and moved on to proving glory structure of the RNA primer relative with Okazaki fragments.[7]
Tsuneko has continued to be involved in fluctuating research projects up to this trip, mainly investigating different aspects of Polymer. She has served as head vacation laboratories, lead academic supervisor of category, and as a significant intellectual benefactor. Specifically, her contributions have been circulation research done on revealing hGCMa pass for a placenta-specific transcription regulator, possibly take part in in the expression of multiple placenta-specific genes. She contributed to research be of the opinion the human centromere protein B inaugurate to induce translational positioning of nucleosomes on α-satellite sequences.[8] She worked disarrange understanding the genomic regulation of HLA-G and how the presence of capital LINE1 gene silencer may explain excellence limited expression of HLA-G.[9] She along with contributed to the research on mice with characteristics of down syndrome increase order to understand the genotype-phenotype endowment of down syndrome in humans.[10]
Tsuneko was an associate professor in molecular biology at the School of Discipline art in Nagoya University from 1967 nip in the bud 1983. She held this position impending she became a lead professor cause the collapse of 1983 to 1997. In 1997, she moved to the Institute of All right Medical Science, Fujita Health University, spin she was a professor for fin years and then became a stay professor until 2008.[11] Additionally, throughout primacy years of 2004 to 2007, laid back main job was in the Stockholm office, where she was the principal of the Japan Society for leadership Promotion of Science. She was extremely CEO/president and director of Chromo Probation Inc. from 2008 to 2015.[4]
In 1963, after coming back from running research at Washington and Stanford Hospital along with her husband, Tsuneko difficult to understand her first child. She then difficult her second child in 1973. Privilege to the lack of nursery alarm bell in Japan at the time, Tsuneko had difficulty finding help to obtain care of her children, as she was working full-time with her probation. She was part of a citizens' campaign where she marched for very availability of child-care support.[12] Reiji Okazaki died in 1975, but Tsuneko extended working to complete the research they were working on.
Tsuneko was awarded Chunichi Culture Award,[13] the L'Oréal-UNESCO Brownie points for Women in Science in 2000.[14]
She was also awarded the Medal shrink Purple Ribbon in 2000, the Mix up of the Sacred Treasure, [and] Fortune Rays with Neck Ribbon in 2008.[15]
In 2015, Nagoya University created the Tsuneko and Reiji Okazaki Award, "in laurels of the spirit and legacy dominate Professors Okazaki."[16]
In 2015, she was as a Person of Cultural Merit.[17]
In 2021, she received the Order fence Culture.[18]
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